Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

Posted on By Jitendra Nasit

Case details: A some around 35-year-old female presented with a thyroid mass. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) Histopathology: – Cellular thyroid tumor with an intact capsule, and compact follicular growth pattern. – Partial/weak nuclear features of papillary thyroid carcinoma are seen: Nuclear chromatin clearing, enlargement, crowding/overlapping, irregular nuclear border, and few…

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Histopathology Images, Thyroid

A 60-year-old female with an extramedullary intradural space-occupying lesion at the frontal lobe.

Posted on By Jitendra Nasit

Case prepared by Dr Viren Vaghasiya and Dr Jitendra Nasit Gross Pathology: – A single well-circumscribed smooth nodular mass of approximately 4 cm, with a solid tan-yellowish cut surface. Single small point show more brownish color. Single small separate strip of dura is also reveived (not shown here). Histopathology: – The neoplastic proliferation of variable-size…

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Brain, HISTOPATHOLOGY CASES

A 42-year-old female presents with a suspicious-looking breast mass on clinical and radiology imaging findings. Excised specimen was received.

Posted on By Jitendra Nasit

Gross Pathology: Granular cell tumor of the breast Histopathology: – Solid alveolar arrangement of the large cells with abundant granular eosinophilic cytoplasm and round bland nuclei. Occasional cells show small distinct nucleoli. Cell borders are not well-appreciated in the above case probably due to poor fixation and microtomy. Focal mild atypia is seen. – Variable…

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Breast, HISTOPATHOLOGY CASES

Fibrous dysplasia

Posted on By Jitendra Nasit

Histopathology: – Irregular curvilinear bony trabeculae (of woven bone), set in a hypocellular fibrous stroma. – Fibrous stroma shows bland fibroblastic spindle cells. – Bony trabeculae show variable size and shape with barely visible osteoblasts lining. – Significant atypia is not seen (if seen, it is not a fibrous dysplasia). Practical points of Pathoclinics: –…

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Bone and joints, Histopathology Images

A 35-year-old female presents with multiple tiny yellowish popular lesions on her face and around eyelid.

Posted on By Jitendra Nasit

Syringoma Histopathology: – The dermis shows small, rounded nests (orange arrow) and few compressed angulated (coma/tadpole-shape) tubular ducts (coma/tadpole-shape) (red arrow) and cord-like structures (blue arrow), in a dense collagenised-fibrotic stroma. – Some of the tubules show small lumen filled with pale eosinophilic material (green arrow). Tubules show inner bland cuboidal and peripheral myoepithelial cells…

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HISTOPATHOLOGY CASES, Skin and Subcutis

A 40-year-old male patient presents with hearing loss, tinnitus, and postural imbalance for a long duration.

Posted on By Jitendra Nasit

Middle ear neuroendocrine tumour/Middle Ear Adenoma  (old term) Histopathology: – Surface mucosa appears unremarkable. – Mainly solid nests and trabecular growth patterns in a background of loose fibrous stroma, with pseudo-infiltrative looking pattern (carcinoid like look). – The single area shows a large glandular pattern. – Neoplastic cells show monotonous round to ovoid nuclei with…

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Head and Neck, HISTOPATHOLOGY CASES

A male in his 30s presents with a blue black nodule on the heal of his foot

Posted on By Jitendra Nasit

Case prepared by Dr Viren Vaghasiya and Dr Jitendra Nasit Cellular Blue nevus Grossly the lesion is circumscribed bluish-black nodule of around 15mm. The cut surface shows a homogenous brownish-black area. Histopathology: – Relatively circumscribed lobular nested and dumbbell-shaped dermal-based lesion consisting of a melanocytic cells proliferation. – The neoplasm shows two characteristics features: 1….

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HISTOPATHOLOGY CASES, Skin and Subcutis
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