Marginal zone lymphoma (MZL) Lymph node

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Nodal MZL

Histopathology:

1. Partial preservation of nodal architecture
2. Small to medium size, centrocyte like irregular cells, infiltrate intrafollicular region and sinus
3. some of the cells shows plasmacytoid looks as well as with pale/clear cytoplasm
4. Pale staining marginal zone cells surrounding the follicles

Points of Pathoclinics:

1. Always search for the extra nodal involvement, as it is commonly seen in 50% of cases
2. Marginal zone cells/tumor cells are BCL2 + while reactive follicles are BCL2 – in nodal MZL, important in differentiation from follicular lymphoma
3. CD5,CD10 and CD23 all –
4. Reactive lymph node in case of Toxoplasmosis or HIV is very close in differentials.