A 67 year old man, presents with dull abdominal pain, weight loss and mild elevation of hepatic enzymes. Radiology suggest hepatomegaly. Liver biopsy for evaluation.
Hepatic Amyloidosis Histopathology: Diffuse extensive acellular pink amorphous deposit (amyloid) is seen in the sinusoids and peri-sinusoidal space (space of Disse). Few atrophic liver-cell plates Sinusoids are markedly compressed by amyloid Inspissated bile is seen in hepatocytes (cholestasis). Globular amyloid deposits are not seen Blood vessels are apparent due to extensive amyloid deposition. Practical points…
