Category: Skin and Subcutis

Syringoma Histopathology: – The dermis shows small, rounded nests (orange arrow) and few compressed angulated (coma/tadpole-shape) tubular ducts (coma/tadpole-shape) (red arrow) and cord-like structures (blue arrow), in a dense collagenised-fibrotic stroma. – Some of the tubules show small lumen filled with pale eosinophilic material (green arrow). Tubules show inner bland cuboidal and peripheral myoepithelial cells…

Continue reading… “A 35-year-old female presents with multiple tiny yellowish popular lesions on her face and around eyelid.” »

Case prepared by Dr Viren Vaghasiya and Dr Jitendra Nasit Cellular Blue nevus Grossly the lesion is circumscribed bluish-black nodule of around 15mm. The cut surface shows a homogenous brownish-black area. Histopathology: – Relatively circumscribed lobular nested and dumbbell-shaped dermal-based lesion consisting of a melanocytic cells proliferation. – The neoplasm shows two characteristics features: 1….

Continue reading… “A male in his 30s presents with a blue black nodule on the heal of his foot” »

Case prepared by Dr Naushin Ghori. Edited by Dr Jitendra Nasit DETAILED CASE HISTORY: A 35-year-old female presents with skin lesions over left side upper back, which are associated with intermittent itching and dull aching pain for five years. Clinical examination revealed multiple small plaque-like, papulo-nodular brownish lesions on skin with underlying mass of approximately…

Continue reading… “A 35-year-old female presents with skin lesions over left side upper back. Skin biopsy for evaluation.” »

Mast cells in cutaneous mastocytosis (Toluidine blue stain) Histopathology: (Toluidine blue stain) Low power images highlight the dense band like infiltrate of mast cells in papillary and reticular dermis. Perivascular mast cells aggregates are seen. Subcutaneous tissues and deep dermal adnexal structures are spared. High power images show ovoid epithelioid mast cells with abundant basophilic-purplish…

Continue reading… “A 2 year old male baby present with a maculo-papular skin lesion. Skin biopsy (Toluidine blue stain) for evaluation.” »

Combined Merkel cell carcinoma with squamous cell carcinoma Histopathology: Predominantly solid diffuse and infiltrative pattern, comprising of both small cell and squamous component. Small cell shows high N:C ratio, round / oval / molded nuclei, finely salt and pepper chromatin pattern, indistinct nucleoli and scant cytoplasm. Squamous component shows nests of squamous cells with moderate…

Continue reading… “A case of around 60 year old female, two skin lesion on thigh. Larger one is approximately 2.5×2.5 cm and smaller lesion measures 1.5×1 cm. No other complaints” »