pathoclinics.com
Histopathology: Histologic features of both endogenous ochronosis (alkaptonuria) and exogenous ochronosis are similar. Curved banana shaped or rounded, yellow-brown to greyish-black coloured, ochronotic bodies/ochre pigmentation, affecting degenerating collagen and elastic fibre (green area), in the superficial dermis and connective tissue. Pigment incontinence with increased melanin in dermis and macrophages (blue area) Epidermis appears unremarkable. Features…
Darier Disease Histopathology: Columns of parakeratosis above acantholytic and dyskeratotic cells (red arrow) Many areas of suprabasal clefts in epidermis (blue arrow) Acantholytic dyskeratosis (orange arrow) Corpus ronds: acantholytic dyskeratotic cells in granular and spinous layers (yellow circle) Grains: acantholytic parakeratotic cells (green circle) Scanty perivascular lymphocytic cells infiltrate in superficial dermis
Histopathology: Hyperplastic acanthotic epidermis show invagination of epidermal cells in dermis. The keratinocytes show large round to ovoid, dense eosinophilic intracytoplasmic inclusions (Molluscum bodies/ Henderson-Paterson bodies, marked with blue arrow) with peripheral displacement of dark blue nuclei (marked with green arrow). Marked areas with red arrow highlight the numerous small pink granules, which fuse and…